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. 2016 Dec 15;27(25):4033–4042. doi: 10.1091/mbc.E16-08-0564

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© 2016 Alli-Balogun et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 2: — Depletion of PI4KIIβ induces invadopodia formation. (A) Confocal images showing immunostaining of cortactin (green) and F-actin (red). (B) Confocal images showing comparisons between HeLa cells transfected with PI4KIIβ siRNA and cells treated with 50 nM PMA. (C–F) Confocal images showing cells grown on thick layers of collagen and coimmunostained for MT1-MMP (magenta), (C) cortactin (green), or (D) β1-integrin (green). (E, F) XZ rendering of 20 confocal sections acquired at 0.25-μm intervals, showing localization of MT1-MMP to ventral structures containing cortactin (E) or β1-Integrin (F). Horizontal lines indicate the position of the ECM surface. Scale bars, 20 μm.