Fig. 4.
The promoted drug release triggered by the LGFU system. (A) DOX concentration comparison between PBS and degassed PBS (18 mJ, 30 s). (B) DOX-release amount at the focal point and 3 mm away (along the axial direction) from the focal point; treated by 18 mJ excitation during 30 s. (C and D) The release concentration upon variation of LGFU parameters: (C) input energy changes at a fixed duration of 3 min; (D) treatment duration changes at a fixed laser energy of 18 mJ. Data represents mean ± SD (n = 3).