Table 1.
Patient Demographics
| All Patients | KU | Spanish | P* | |
|---|---|---|---|---|
| (N=190) | (N=69) | (N=121) | ||
| Age at Diagnosis (years) (Median , Range) |
51 (29–81) |
52 (30–80) |
50 (29–81) |
0.86 |
| Race | ||||
| Caucasian | 174 (92%) | 57 (83%) | 117 (96%) | <0.001 |
| Black | 14 (7%) | 12 (17%) | 2 (2%) | |
| Asian | 2 (1%) | 0 (0%) | 2 (2%) | |
| Ethnicity | ||||
| Hispanic | 26 (14%) | 2 (3%) | 24 (20%) | 0.001 |
| Non-Hispanic | 163 (86%) | 67 (97%) | 97 (80%) | |
| Menopausal status | ||||
| Pre/Peri | 86 (45%) | 30 (44%) | 56 (46%) | 0.59 |
| Post | 98 (52%) | 38 (55%) | 60 (50%) | |
| Unknown | 6 (3%) | 1 (1%) | 5 (4%) | |
| T Stage Number | ||||
| 1 | 23 (12%) | 19 (27%) | 4 (3%) | <0.001 |
| 2 | 104 (55%) | 37 (54%) | 67 (55%) | |
| 3 | 34 (18%) | 11 (16%) | 23 (19%) | |
| 4 | 29 (15%) | 2 (3%) | 27 (23%) | |
| Median Tumor Size (mm) (range) |
35 (9–180) | 30.5 (10–111) | 41(9–180) | <0.001 |
| Lymph Node Status | ||||
| Negative | 90 (47%) | 47 (68%) | 43 (35%) | <0.001 |
| Positive | 98 (52%) | 22 (32%) | 76 (63%) | |
| Unknown | 2 (1%) | 0 (0%) | 2 (2%) | |
| TNM Stage | ||||
| I | 20 (11%) | 18 (26%) | 2 (2%) | <0.001 |
| II | 107 (56%) | 41 (59%) | 66 (54%) | |
| III | 63 (33%) | 10 (15%) | 53 (44%) | |
| ER/PR | ||||
| 0% | 184 (97%) | 63 (91%) | 121(100%) | 0.001 |
| 1–10% | 6 (3%) | 6 (9%) | 0 (0%) | |
| Germline BRCA Mutation | ||||
| Absent | 136 (71%) | 49 (71%) | 87 (72%) | 0.084 |
| Present | 30 (16%) | 15 (22%) | 15 (12%) | |
| Unknown | 24 (13%) | 5 (7%) | 19 (16%) | |
| Surgery type# | ||||
| Lumpectomy | 84 (45%) | 23 (33%) | 61 (53%) | 0.045 |
| Mastectomy | 101 (55%) | 46 (67%) | 55 (47%) | |
| Axillary surgery | ||||
| Pre NAC SLNB | 24 (13%) | 0 (0%) | 24 (20%) | <0.001 |
| Post NAC | ||||
| SLNB without ALND | 50 (27%) | 46 (66%) | 4 (3%) | <0.001 |
| SLNB plus ALND | 15 (8%) | 6 (9%) | 9 (8%) | |
| ALND | 94 (50%) | 15 (22%) | 79 (66%) | |
| No axillary procedure | 5 (2%) | 2 (3%) | 3 (3%) | |
| Positive family History⍰ | ||||
| Yes | 52 (28%) | 27 (39%) | 25 (21%) | 0.11 |
| No | 136 (72%) | 42 (61%) | 94 (79%) | |
*
Mann-Whitney non-parametric test for continuous data; Pearson Chi-Square/Fisher Exact test for categorical data.
#
Surgical information was not available for 5 patients in the IIT population.
⍰
Family history information was not available for 2 patients from Spanish-cohort. Family history is reported utilizing cohort specific definitions of positive family history as outlined in patient characteristics section. Upon application of Spanish family history definition to the entire study population, 24% of patients had positive family history