Table 3.
Predictors of pathological complete response on univariate analysis#
| OR | 95% CI | P* | |
|---|---|---|---|
| Age | |||
| ≤50 | 1 | ||
| >50 | 0.74 | 0.4, 1.33 | 0.37 |
| LN status | |||
| Negative | 1 | ||
| Positive | 0.71 | 0.39, 1.27 | 0.30 |
| T stage | |||
| T1/2 | 1 | ||
| T3/4 | 0.39 | 0.21,0.73 | 0.003 |
| TNM stage | |||
| I/ II | 1 | ||
| III | 0.35 | 0.19, 0.67 | 0.001 |
| gBRCA mutation | |||
| Negative/unknown | 1 | ||
| Positive | 1.25 | 0.54, 2.86 | 0.68 |
| Family History | |||
| No | 1 | ||
| Yes | 0.96 | 0.5, 1.85 | 1.0 |
| Cohort | |||
| Spanish | 1 | ||
| KU | 1.93 | 1.04, 3.50 | 0.046 |
*
Odds ratios (ORs) and 2-sided P values from Fisher’s exact test.
#
On multivariable logistic regression analysis (factors included: age, lymph node status, T stage, TNM stage, germline BRCA mutation status, family history and cohort type) presence of TNM stage III disease was the only factor associated with a lower likelihood of achieving a pCR (HR 0.35, 95% CI: 0.19, 0.67)