Table 3.
Urinary biomarkers of exposure expressed as quantity excreted, ratios of THS relative to CC.
| Biomarkers | Ratioa(% and CI) |
|---|---|
| THS (N=81)/ CC (N=41) | |
| NEQ (mg/g creat) | 97.98 (80.98, 118.54) |
| Total NNAL (pg/mg creat) | 42.79 (37.40; 48.95) |
| Total NNN (pg/mg creat) | 23.45 (17.12, 32.12) |
| MHBMA (pg/mg creat) | 8.17 (6.70; 9.96) |
| 3-HPMA (ng/mg creat) | 40.49 (35.84; 45.74) |
| S-PMA (pg/mg creat) | 5.87 (5.03; 6.85) |
| Total 1-OHP (pg/mg creat) | 43.43 (37.67; 50.06) |
| 4-ABP (pg/mg creat) | 14.55 (12.51; 16.92) |
| 1-NA (pg/mg creat) | 3.66 (3.06; 4.37) |
| 2-NA (pg/mg creat) | 11.22 (9.75; 12.91) |
| o-tol (pg/mg creat) | 40.38 (34.92, 46.68) |
| CEMA (ng/mg creat) | 12.96 (11.15, 15.06) |
| HEMA (pg/mg creat) | 31.37 (26.51, 37.11) |
| 3- HMPMA (ng/mg creat) | 21.85 (18.83; 25.36) |
| Total 3-OH-B[a]P (fg/mg creat) | 26.62 (22.33, 31.74) |
a
Ratio: Geometric least squares mean ratio (%) and confidence intervals from an ANCOVA model conducted on log-transformed Day 5 values (urinary biomarker of exposure expressed as quantity) with log-transformed baseline value, study arm, sex and CC consumption reported at screening as fixed effect factors (THS/CC) on Day 5. Abbreviations: NC=not calculated. CC=conventional cigarette group; CI: Confidence interval; THS=Tobacco Heating System 2.2 group.