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. 2016 Dec 15;7:2007. doi: 10.3389/fmicb.2016.02007

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Copyright © 2016 Maryam and Khan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synergistic effect of streptomycin and cefotaxime on CTX-M-15. (A) shows inability of cell killing by cefotaxime due to its hydrolysis by CTX-M-15 enzyme. (B) shows cellular lyses by available un-hydrolyzed cefotaxime due to streptomycin which leads to reduced binding of cefotaxime on its active site of hydrolysis.