Table 2.
Spectral characteristics of CTX-M-15 under different drug binding conditions.
| MRE208 (deg.cm2.dmol−1) | % α helix at 208 | MRE222 (deg.cm2.dmol−1) | % α helix at 222 | |
|---|---|---|---|---|
| CTX-M-15 | −14,070 ± 210 | 34.72% | −14,004.9 ± 145 | 38.49% |
| CTX-M-15+CTX | −12,500.1 ± 161 | 29.31% | −20,842.9 ± 132 | 61.06% |
| CTX-M-15+CTX+STR | −20,524.3 ± 170 | 56.98% | −30,313.2 ± 126 | 92.32% |
| CTX-M-15+CTX+FOX | −7,744.89 ± 157 | 12.91% | −21,163.5 ± 201 | 62.12% |
| CTX-M-15+CTX+FOX+STR | −10,322.8 ± 190 | 21.8% | −22,061.1 ± 138 | 64.93% |
| CTX-M-15+CTX+STR+FOX | −12,871 ± 173 | 30.58% | −26,010.9 ± 223 | 78.12% |
| CTX-M-15+STR | −10,760.6 ± 102 | 23.3% | −20,096.1 ± 139 | 58.60% |
| CTX-M-15+STR+CTX | −21,577.9 ± 189 | 60.61% | −27,178.1 ± 159 | 81.97% |
| CTX-M-15STR+FOX | −12,972.1 ± 144 | 30.93% | −21,621.4 ± 149 | 63.63% |
| CTX-M-15+STR+FOX+CTX | −11,166.3 ± 204 | 24.71% | −27,848.7 ± 187 | 84.81% |
CTX, cefotaxime; STR, streptomycin; FOX, cefoxitin.
MRE values are reported as the average of ± standard error from three independent experiment.