Table 1.
Mouse model | Reduced body weight | Onset (weeks) | Impairments in rotarod | Onset (weeks) | Anomalies in footprint | Onset (weeks) | Clasping | Onset (weeks) | Impairments in the beamwalk | Onset (weeks) |
---|---|---|---|---|---|---|---|---|---|---|
Q58 | NA | Yes | 16 | Yes | 16 | Yes | 32 | Yes | 32 | |
Q75 | NA | Yes | 6 | NA | NA | NA | ||||
Q42KI | Yes | 1 | Yes | 72 | NE | NA | NA | |||
Q127 | NA | Yes | 8 | NA | NA | NA | ||||
BAC-Q72 | Yes | 8 | Yes | 16 | NA | NA | NA |
Behavioral hallmarks of the mouse models of SCA2. For each model, the symptoms/characteristics are included as existent (“Yes”), non-existent (“NE”), or Not available (“NA”), with the corresponding age of onset.