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. 2016 Dec 15;7:1995. doi: 10.3389/fmicb.2016.01995

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Copyright © 2016 Healey, Jimenez Ortigosa, Shor and Perlin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Electrophoretic karyotypes of three pairs of serial C. glabrata clinical isolates. (A) The minimum inhibitory concentrations (MIC), sequence type (ST), and genome mutations of two bloodstream isolates (A and B) from three individual patients (1, 2, and 3) are shown. (B) Karyotypes of the same isolates obtained with PFGE analysis. The karyotype of the C. glabrata reference strain CBS138/ATCC2001 is also shown. M: CHEF DNA chromosomal size marker (S. cerevisiae strain YNN295) (BIO-RAD). ANF, anidulafungin; MCF, micafungin; CSF, caspofungin; FLZ, fluconazole. ^*Gain of function mutations.