Table 4.
Integration of ultrasound with pediatric appendicitis score (PAS) and C-reactive protein (CRP) in the diagnosis of pediatric appendicitis.
| US positive N (% appendicitis) |
US negative N (% appendicitis) |
Patients (N) |
|
|---|---|---|---|
| PAS | |||
| 0–3 | 7 (0%) | 116 (0%) | 123 |
| 4–6 | 59 (93%) | 143 (7%) | 202 |
| 7–10 | 40 (100%) | 37 (31%) | 77 |
|
| |||
| CRP (mg/L) | |||
| <15 | 36 (89%) | 191 (5%) | 227 |
| ≥15 | 74 (91%) | 122 (8%) | 196 |
|
| |||
| PAS ≤ 5 + CRP < 5 | 9 (50%) | 118 (3%) | 127 |
|
| |||
| Diagnostic performance% (95% CI) | |||
|
| |||
| Negative US + CRP < 15 | Sens. 92 (85–96), spec. 60 (54–65), PPV 47 (40–54), NPV 95 (91–97), LR+ 2.26 (1.95–2.60), LR− 0.14 (0.08–0.26) | ||
|
| |||
| Negative US + PAS ≤ 5 + CRP < 5 | Sens. 98 (92–99), spec. 41 (36–48), PPV 39 (34–46), NPV 98 (92–99), LR+ 1.66 (1.45–2.01), LR− 0.05 (0.03–0.15) | ||
US: ultrasound; CRP: C-reactive protein; PAS: pediatric appendicitis score; PPV: positive predictive value; NPV: negative predictive value; CI: confidence interval; LR: likelihood ratio; patients lacking PAS (N = 36) or CRP (N = 15) were not included.