Table 3.
Dosing summary for rat pharmacokinetic studies. Epothilone D free drug was dosed at 10 and 20 mg/kg. IT-147 was dosed at 10, 20, 30, and 40 mg/kg epothilone D equivalent or 500, 1000, 1500, and 2000 mg/kg formulation, respectively.
| Test article | Dose epothilone D (mg/kg) | Dose IT-147 (mg/kg) |
Epothilone D concentration (mg/mL) |
IT-147 concentration (mg/mL) |
Test article volume (mL) |
|---|---|---|---|---|---|
| Epo D | 10 | 0 | 1.15 | 0 | 2 |
| Epo D | 20 | 0 | 2.3 | 0 | 2 |
| IT-147 | 10 | 500 | 1.15 | 57.5 | 2 |
| IT-147 | 20 | 1000 | 2.30 | 115 | 2 |
| IT-147 | 30 | 1500 | 3.45 | 173 | 2 |
| IT-147 | 40 | 2000 | 4.60 | 230 | 2 |