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. 2016 Dec 15;7:483. doi: 10.3389/fphar.2016.00483

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Copyright © 2016 Li, Tu, Gao, Wang, Zhang, Niu, Li, Zhang, Li, Xiao, Yang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Orthogonal partial least squares-discriminant analysis (OPLS-DA) analysis of the data generated from the ESI- mode. S-score plots constructed from the supervised OPLS analysis of serum (B,D,F), the axes that are plotted in the S-plot from the predictive component are p1 vs. p(corr)1, representing the magnitude and reliability, respectively. Metabolite ions with variable influence on the projection (VIP) value >1 were marked with a red square. (A,B) Displays the result of OPLS-DA model using the data from the LPS/EA and LPS/CH groups in ESI- mode. (C,D) Displays the result of OPLS-DA modelusing the data from the LPS/EA and LPS/RE groups in ESI- mode. (E,F) Displays the result of OPLS-DA model using the data from the LPS/EA, LPS/CH and LPS/RE groups in ESI- mode.