Table 1.
Identification and trends of change for potential biomarkers.
| Nob | R.T. (min) | Biomarkers | Mass | Formula | Content variancea |
|---|---|---|---|---|---|
| ESI+ | |||||
| 1 | 0.94 | L-Valine | 117.0790 | C5H11NO2 | ↓ |
| 2 | 1.09 | Creatine | 131.0695 | C4H9N3O2 | ↓ |
| 3 | 1.09 | Nicotinamide | 122.0480 | C6H6N2O | ↑ |
| 4 | 3.97 | epsilon-Caprolactam | 113.0841 | C6H11NO | ↑ |
| 5 | 13.57 | Sphingosine | 299.2824 | C18H37NO2 | ↓ |
| 6 | 14.86 | Orthophosphate | 97.9769 | H3O4P | ↓ |
| 7 | 15.85 | UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine | 1007.2774 | C34H55N7O24P2 | ↑ |
| 8 | 19.72 | Sphinganine 1-phosphate | 381.2644 | C18H40NO5P | ↓ |
| 9 | 19.89 | Cortol | 368.2563 | C21H36O5 | ↓ |
| ESI- | |||||
| 1 | 0.84 | Succinate | 118.0266 | C4H6O4 | ↑ |
| 2 | 0.85 | D-Lombricine | 270.0729 | C6H15N4O6P | ↓ |
| 3 | 0.93 | Oxalosuccinate | 190.0114 | C6H6O7 | ↑ |
| 4 | 0.94 | Urate | 168.0283 | C5H4N4O3 | ↑ |
| 5 | 0.94 | gamma-Glutamyl-gamma-aminobutyraldehyde | 216.1110 | C9H16N2O4 | ↓ |
| 6 | 0.94 | 2-C-Methyl-D-erythritol 4-phosphate | 216.0399 | C5H13O7P | ↓ |
| 7 | 0.98 | O-Succinyl-L-homoserine | 219.0743 | C8H13NO6 | ↑ |
| 8 | 1.11 | Caproic acid | 116.0837 | C6H12O2 | ↓ |
| 9 | 1.13 | 4-Pyridoxic acid | 183.0532 | C8H9NO4 | ↓ |
| 10 | 5.38 | Phenol | 94.0419 | C6H6O | ↑ |
| 11 | 9.69 | Imidazole lactate | 156.0535 | C6H8N2O3 | ↓ |
| 12 | 19.83 | beta-Nitropropanoate | 119.0219 | C3H5NO4 | ↑ |
aChange trends of potential biomarkers in LPS/EA compared with LPS/CH and LPS/RE groups. bPotential biomarkers identified both in positive and negative electrospray ionization source (ESI) mode. The levels of potential biomarkers were marked with (↓) down-regulated, (↑) up-regulated.