Figure 8.

Car3-KO prevents the acidosis-caused prolongation of relaxation in mouse soleus muscle. (A) Car3-KO and WT soleus muscles showed no significant difference in tetanic force production at both normal extracellular pH (5% CO₂), which decreased by similar degrees at acidotic extracellular pH (30% CO₂). (B) Acidotic extracellular pH produced a significant prolongation of the time for 50% and 75% relaxation (TR50 and TR75) post tetanic contraction in WT soleus muscle. Car3-KO minimized this acidosis-caused slowdown of relaxation. The data are presented as mean ± SE. N = 6 mice each in WT and Car3-KO groups. ^*P < 0.05 vs. WT in Student's t-test. ^##P < 0.01 vs. 5% CO₂ in paired Student's t-test.