Table 7:
GRADE Evidence Profile for Effectiveness, Comparison of TAVI and SAVR
| Number of Studies (Design) | Risk of Bias | Inconsistency | Indirectness | Imprecision | Publication Bias | Upgrade Considerations | Quality |
|---|---|---|---|---|---|---|---|
| NYHA Functional Class | |||||||
| 4 (RCTs) | No serious limitations | Undetermined | No serious limitations | No serious limitations | Undetected | None | ⊕⊕⊕ Moderate |
| Quality of Life | |||||||
| 3 (RCTs) | Serious limitations (−2)a | Undetermined | No serious limitations | No serious limitations | Undetected | None | ⊕⊕Low |
Abbreviations: GRADE, Grading of Recommendations Assessment, Development and Evaluation; RCT, randomized controlled trial; SAVR, surgical aortic valve replacement; TAVI, transcatheter aortic valve implantation.
a
High rate of missing data at baseline and follow-up. Assessments were unblinded.