#	Searches	Results
1	exp Aortic Valve Stenosis/	45048
2	((supravalvular or subvalvular or aort*) adj2 stenos?s).ti,ab.	35594
3	or/1–2	63767
4	Heart Valve Prosthesis Implantation/	25899
5	exp Heart Valve Prosthesis/	59222
6	(((aorta or aortic) adj2 (replace* or implant* or prosthe* or bioprosthe* or transplant*)) or avr).tw.	50800
7	or/4–6	107185
8	(transcatheter* or trans-catheter* or transfemoral or trans-femoral or transapical or trans-apical or percutaneous).tw.	298945
9	exp Surgical Procedures, Minimally Invasive/	447042
10	(minimal* adj3 (surgery or surgeries or surgical or procedure* or invasive)).tw.	116422
11	or/8–10	765541
12	7 and 11	18249
13	Transcatheter aortic valve implantation/	8455
14	(core-valve or corevalve or Cribier Edwards or Edwards valve* or Edwards Sapien or Sapien XT or Sapien 3 or Portico or Lotus or Evolut R or (transcatheter adj (heart or aortic) adj valve adj2 (replace* or implant*)) or TAVI or TAVR).tw.	17191
15	or/12–14	25185
16	3 and 15	9378
17	Meta-Analysis/ or Meta-Analysis as Topic/ or exp Technology Assessment, Biomedical/	210519
18	Meta Analysis.pt.	60866
19	(((systematic* or methodologic*) adj3 (review* or overview*)) or pooled analysis or published studies or published literature or hand search* or handsearch* or medline or pubmed or embase or cochrane or cinahl or data synthes* or data extraction* or HTA or HTAs or (technolog* adj (assessment* or overview* or appraisal*))).tw.	486314
20	(meta analy* or metaanaly* or health technolog* assess*).mp.	315567
21	Clinical Trials as Topic/ or Randomized Controlled Trials as Topic/	432485
22	(randomized controlled trial or controlled clinical trial).pt.	933021
23	trial.ti.	479103
24	(randomi#ed or randomly or RCT$1 or placebo* or sham).tw.	2225905
25	or/17–24	3341673
26	exp Animals/ not (exp Animals/ and Humans/)	9130432
27	25 not 26	2975802
28	16 and 27	1052
29	Case Reports/ or congresses.pt.	1840122
30	28 not 29	1046
31	30 use pmoz	396
32	16 use cctr,coch,dare,clhta,cleed	172
33	or/31–32	568
34	limit 33 to (english language and yr=“2011 -Current”) [Limit not valid in CDSR,DARE; records were retained]	451
35	exp aorta valve stenosis/	12332
36	((supravalvular or subvalvular or aort*) adj2 stenos?s).ti,ab.	35594
37	or/35–36	41383
38	aorta valve replacement/	15778
39	exp aorta valve prosthesis/	4917
40	(((aorta or aortic) adj2 (replace* or implant* or prosthe* or bioprosthe* or transplant*)) or avr).tw.	50800
41	or/38–40	57155
42	(transcatheter* or trans-catheter* or transfemoral or trans-femoral or transapical or trans-apical or percutaneous).tw.	298945
43	exp minimally invasive surgery/	445320
44	(minimal* adj3 (surgery or surgeries or surgical or procedure* or invasive)).tw.	116422
45	or/42–44	763980
46	41 and 45	15077
47	transcatheter aortic valve implantation/	8455
48	(core-valve or corevalve or Cribier Edwards or Edwards valve* or Edwards Sapien or Sapien XT or Sapien 3 or Portico or Lotus or Evolut R or (transcatheter adj (heart or aortic) adj valve adj2 (replace* or implant*)) or TAVI or TAVR).tw.	17191
49	or/46–48	22287
50	37 and 49	7790
51	Meta Analysis/ or “Meta Analysis (Topic)“/ or Biomedical Technology Assessment/	199702
52	(((systematic* or methodologic*) adj3 (review* or overview*)) or pooled analysis or published studies or published literature or hand search* or handsearch* or medline or pubmed or embase or cochrane or cinahl or data synthes* or data extraction* or HTA or HTAs or (technolog* adj (assessment* or overview* or appraisal*))).tw.	486314
53	(meta analy* or metaanaly* or health technolog* assess*).mp.	315567
54	exp “controlled clinical trial (topic)“/	86666
55	randomized controlled trial/ or controlled clinical trial/	1021271
56	trial.ti.	479103
57	(randomi#ed or randomly or RCT$1 or placebo* or sham).tw.	2225905
58	or/51–57	3206603
59	(exp animal/ or nonhuman/) not exp human/	9484953
60	58 not 59	2909809
61	50 and 60	978
62	Case Report/ or conference abstract.pt.	5721661
63	61 not 62	754
64	limit 63 to (english language and yr=“2011 -Current”) [Limit not valid in CDSR,DARE; records were retained]	610
65	64 use emez	326
66	34 or 65	777
67	66 use pmoz	305
68	66 use emez	326
69	66 use cctr	99
70	66 use coch	3
71	66 use dare	9
72	66 use clhta	18
73	66 use cleed	17
74	remove duplicates from 66	493