Table 1.

Demographic data and group comparison of cognitive scores, MRI measures and measures of network topology.

	Controls	MCI	t statistic (df); p
Age (yrs.)	74.0 (6.5)	76.8 (7.3)	1.3 (43); 0.19
Education (yrs.)	15 (3)	14 (4)	1.8 (43); 0.08
NART-R IQ	120 (9)	115 (11)	1.8 (43); 0.08
Percentage females	50%	44%
Cognitive measures
Category fluency	39.5 (10.9)	25.6 (7.9)	4.9 (41); <0.001
Verbal fluency	43.2 (13.1)	35.9 (11.3)	1.9 (41); 0.067
Digit symbol substitution	56.5 (18.6)	34.8 (11.9)	4.6 (40); <0.001
Stroop suppression	93.4 (19.1)	57.4 (28.2)	4.7 (40); <0.001
Tower of London rule violations	1.2 (1.7)	5.8 (4.5)	4.2 (41); <0.001
Trails switching	74.0 (31.6)	105.4 (50.7)	2.4 (42); 0.021
FCSRT free recall	29.3 (8.4)	12.1 (9.7)	6.2 (42); <0.001
CRMT face recognition	23.4 (2.8)	20.0 (3.4)	3.6 (41); <0.001
MRI – general measures
NBV (ml)	1,451.4 (57.4)	1,421.7 (57.4)	1.7 (43); 0.091
WML volume (cm)	15.6 (6.7)	19.6 (10.3)	1.5 (41); 0.15
Structural network properties
Global efficiency	0.0260 (0.0021)	0.0239 (0.0036)	2.6 (39.6); 0.014
Mean clustering coefficient	18.1 (1.9)	16.7 (2.3)	2.2 (43); 0.037
Small-worldness	1.90 (0.26)	1.95 (0.28)	0.63 (43); 0.53

Data are shown as mean (SD). A cube root transform was applied to white matter lesion volume. Significant differences (p < 0.05) are highlighted in bold.

MCI – Mild Cognitive Impairment; NART-R – National Adult Reading Test-Revised; FCSRT – Free and Cued Selective Reminding Test; CRMT – Camden Recognition Memory Test; NBV – normalized brain volume; WML – white matter lesion