A, METH (20 mg kg–1, s.c.) induced change in core body temperature of WT (black) UCP3KO (blue) and SKMTg‐UCP3KO (green, n = 9) mice. B, METH (20 mg kg–1, s.c.) induced change in core body temperature of UCPDK (orange) and SKMTg‐UCPDK (magenta, n = 4) mice. C, LPS (50 μg kg–1, i.p.) induced change in core body temperature of wild‐type (black line) and SKMTg‐UCP3KO (green, n = 4) mice. D, LPS (50 μg kg–1, i.p.) induced change in core body temperature of SKMTg‐UCP3KO (green) and UCP3KO (blue) mice. Dotted lines represent ± SEM. Black bars represent significance between groups with Welsh's two‐tailed t test, P ≤ 0.05. [Colour figure can be viewed at wileyonlinelibrary.com]