Table 1.
Electrophysiological parameters of control and biotin‐deficient glomus cells
| Control | Biotin‐deficient | P (t test) | Voltage‐clamp configuration | |
|---|---|---|---|---|
| Input resistant (GΩ) | 6.8 ± 0.5 (n = 30) | 5.8 ± 0.5 (n = 21) | 0.19 | Perforated patch |
| V m resting (mV) | −53.6 ± 2.1 (n = 32) | −49.8 ± 1.8 (n = 24) | 0.18 | Perforated patch |
| Cell capacitance (pF) | 4.8 ± 0.3 (n = 50) | 4.5 ± 0.4 (n = 37) | 0.54 | Whole cell. Dialysed cells |
| Peak K+ current (V m = +50 mV (pA) | 411.9 ± 87.9 (n = 23) | 397.5 ± 55.3 (n = 20) | 0.89 | Perforated patch |
| Peak Na+ current (V m = +10 mV (pA) | −61.3 ± 17.0 (n = 12) | −62.8 ± 12.0 (n = 23) | 0.94 | Whole cell. Dialysed cells |
| Peak Ca2+ current (V m = 0 mV (pA) | −7.1 ± 0.8 (n = 40) | −6.5 ± 0.7 (n = 33) | 0.63 | Whole cell. Dialysed cells |
| Fast deactivating Ca2+current density (pA pF–1) | −34 ± 4 (n = 50) | −39 ± 4 (n = 36) | 0.41 | Whole cell. Dialysed cells |
| Slow deactivating Ca2+ current density (pA pF–1) | −7 ± 1 (n = 48) | −5 ± 1 (n = 33) | 0.24 | Whole cell. Dialysed cells |
| Tau fast deactivating Ca2+ current (μs) | 105 ± 6 (n = 50) | 97 ± 5 (n = 37) | 0.32 | Whole cell. Dialysed cells |
| Tau slow deactivating Ca2+ current (ms) | 1.0 ± 0.1 (n = 48) | 1.28 ± 0.14 (n = 34) | 0.09 | Whole cell. Dialysed cells |