Figure 1.

A, Restraint stress significantly decreased the time spent in the light side of the compartment. Pretreatment with pioglitazone (30 mg/kg) reversed the anxiogenic-like effect of stress. B, No differences were detected in the number of entries into the light side of the arena. The data represent the mean ± SEM values (n = 12–13 per group). Difference between vehicle nonstressed and vehicle stressed: ***p < 0.001. Difference between vehicle stressed and pioglitazone stressed: ## p < 0.01.