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. 2016 Dec 14;36(50):12624–12639. doi: 10.1523/JNEUROSCI.1300-16.2016

Figure 4.

Figure 4.

Flow/pressure-evoked changes in neuronal network activity. A, Representative DIC and fluorescence images showing the position of the patched neuron relative to the cannulated arteriole. Top row, Patched neuron ∼150 μm away from the cannulated arteriole. Bottom row, Patched neuron ∼300 μm away from the cannulated arteriole. Scale bar, 25 μm. B, Summary data of changes in neuronal firing rate induced by a modest increase in flow rate (0.1 to <0.5 μl/min, ↑Q) grouped according to proximity to the cannulated arteriole. C, Representative traces of diameter changes (top) in a cannulated arteriole and sEPSC (middle). Bottom, Expanded traces showing sEPSC before (left), during (middle), and after (right) ↑Q. D, Cumulative probability (Prob.) of sEPSC interevent interval (left) before (control), during (↑Q), and after (recovery) the flow/pressure stimulus and summary data of mean sEPSC frequency. E, Cumulative probability plot of amplitude (left) before (control), during (↑Q), and after (recovery) the flow/pressure stimulus and summary of mean sEPSC amplitude (right) Error bars indicate SEM. *p < 0.05 (paired t test). **p < 0.01 (paired t test). ***p < 0.0001 (paired t test).