Figure 2.

Tat-induced NMDAR potentiation requires LRP. A, Representative traces showing NMDA-evoked steady-state whole-cell current from cells treated with Tat for 4 h in the absence and presence of RAP (10 μm) applied 15 min before Tat. NMDA (10 μm) was applied at the time indicated by the horizontal bars. Scale bar, 100 pA, 60 s. B, Bar graph summarizing NMDA-evoked current normalized to whole-cell capacitance from untreated (open bars) cells or cells treated with Tat (solid bars) for 4 h in the presence or absence of RAP. Data are shown as mean ± SEM (n ≥ 5 for all groups). **p < 0.01 relative to untreated control, ##p < 0.01 relative to Tat + RAP-treated (4 h) (one-way ANOVA with Tukey's post hoc test).