Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Dec 14;36(50):12697–12706. doi: 10.1523/JNEUROSCI.2400-16.2016

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 Hörnberg, Cioni et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Figure 4. — Restoring Nrp1 levels rescues the dorsal axon topography defect in Hermes-depleted embryos. Shown is Nrp1 immunostaining on retina transverse sections from atoh7:gapRFP zebrafish embryos injected with CoMO (A), HeMO (B), or HeMO+Nrp1MO (C). Quantifications show a significant increase of Nrp1 signal intensity in the HeMO condition compared with CoMO and HeMO + Nrp1MO (D). Lateral view of whole-mount DiI- and DiO-injected retina from CoMO- (E), HeMO- (F), and HeMO + Nrp1MO (G)-injected embryos. HeMO + Nrp1MO-coinjection showed a significant reduction of the percentage of embryos with mistargeting in the OT compared with HeMO (H). DiI-labelling of dorsal axons in the tectum of CoMO (I), HeMO (J), and HeMO + nrp1MO (K) injected embryos. Quantifications show a rescue of misprojecting dorsal axons in HeMO+nrp1MO injected embryos (L). Error bars indicate SEM. Numbers of embryos analyzed are indicated on bars. Scale bars: A–C, 100 μm; E–G, I–K, 50 μm).