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. Author manuscript; available in PMC: 2016 Dec 15.
Published in final edited form as: Pac Symp Biocomput. 2016;22:414–425. doi: 10.1142/9789813207813_0039

Fig 3.

Fig 3

(A) High frequency mutations are significantly biased towards high impact mutations (Pvalue=5*10−28) while low frequency mutations are biased towards low predicted impact (Pvalue 2.5*10−05). Mean=diamond Median=red line Whisk=2STD (B) Observed kinase mutation rate compared to computer simulation of random mutations. BRAF and CHEK2 (550 and 160 mutations, respectively) not shown on plot.