Table 1. Subject characteristics in obese and nonobese, dyslipidemic children.
Group 1 | Group 2 | P value | |
---|---|---|---|
Number | 15 | 23 | |
Male Gender (%) | 6 (40) | 14 (61) | 0.320 |
Age (yr) | 13 ± 3 | 14 ± 4 | 0.295 |
Height (cm) | 160 ± 13 | 159 ± 17 | 0.759 |
BMI (%) | 98 ± 1 | 59 ± 26 | <0.001 |
BMI z score | 2.1 ± 0.3 | 0.3 ± 0.8 | <0.001 |
Waist circ (cm) | 94 ± 14 | 71 ± 10 | <0.001 |
Systolic BP | 112 ± 9 | 109 ± 8 | 0.411 |
Pre-pubertal (%) | 2 (13) | 7 (30) | |
Pubertal (%) | 9 (60) | 4 (17) | 0.026 |
Post-pubertal (%) | 4 (27) | 12 (52) | |
Family Hx CVD (%) | 6 (40) | 8 (35) | 1.000 |
Family Hx DM (%) | 7 (47) | 13 (57) | 0.741 |
Total Chol (mmol/L) | 4.03 ± 0.96 | 5.77 ± 2.15 | 0.005 |
LDL-C (mmol/L) | 2.46 ± 0.62 | 4.19 ± 2.15 | 0.005 |
HDL-C (mmol/L) | 0.96 ± 0.18 | 1.22 ± 0.28 | 0.004 |
TG (mmol/L) | 1.31 ± 0.82 | 0.80 ± 0.41 | 0.016 |
Lp(a) (mg/dL) | 33 ± 40 | 41 ± 29 | 0.475 |
Glucose (mmol/L) | 4.39 ± 0.33 | 4.61 ± 0.44 | 0.302 |
Insulin (μU/mL) | 202 ± 104 | 104 ± 42 | 0.001 |
HbA1C (%) | 5.9 ± 1.3 | 5.4 ± 0.3 | 0.096 |
HOMA-IR | 5.4 ± 2.5 | 3.2 ± 1.6 | 0.002 |
Homocysteine (μmol/L) | 7.6 ± 2.0 | 7.9 ± 1.3 | 0.525 |
25-OH vitamin D (nmol/L) | 52 ± 10 | 69 ± 41 | 0.119 |
hsCRP (mg/L) | 2.44 ± 1.63 | 1.08 ± 2.41 | 0.064 |
IL-6 (pg/mL) | 1.59 ± 0.90 | 0.63 ± 0.47 | <0.001 |
TNF (pg/mL) | 4.85 ± 4.36 | 5.02 ± 2.06 | 0.867 |
Carotid IMT (mm) | 0.42 ± 0.04 | 0.42 ± 0.05 | 0.799 |
Peak response | 1.52 [1.22-1.97] | 2.04 [1.61-2.46] | 0.038 |
Area under the curve (AUC) | 19 ± 4 | 24 ± 6 | 0.010 |