Transmission electron microscopy (TEM) Images of Mtb-FtsZ. Mtb-FtsZ (5 μM) was polymerized by GTP (25 lM) in the absence (A and D) and presence of 80 μM of SB-P3G2 (B) and SB-P17G-C2 (C). Image (E) displays the effect of SB-P17G-C2 (80 μM) on preformed polymers, wherein FtsZ polymers formed after addition of GTP were treated with compound. Images are at 49,000 magnification (scale bar 500 nm). Reprinted with permission from Awasthi, D.; Kumar, K.; Knudson, S. E.; Slayden, R. A.; Ojima, I., SAR Studies on Trisubstituted Benzimidazoles as Inhibitors of Mtb FtsZ for the Development of Novel Antitubercular Agents. J. Med. Chem.
2013,
56 (23), 9756–9770. Copyright 2013 American Chemical Society.