Skip to main content
. Author manuscript; available in PMC: 2017 Dec 15.
Published in final edited form as: Bioorg Med Chem. 2016 May 5;24(24):6354–6369. doi: 10.1016/j.bmc.2016.05.003

Figure 19.

Figure 19

Interaction of CRAMP (16–33) with FtsZ. The N-terminus of FtsZ is blue. The H7 helix is green. The C-terminus is red, and CRAMP (16–33) is magenta. A) Proposed CRAMP (16–33) binding site located near the T7 loop. B) Magnification of CRAMP (16–33) binding site. C) Residue interactions forming salt bridges (green) and hydrogen bonds (orange). Reprinted with permission from SocietyRay, S., Dhaked, H. P., Panda, D., Antimicrobial peptide CRAMP (16–33) stalls bacterial cytokinesis by inhibiting FtsZ assembly. Biochemistry. 2014, 53 (41), 6426–9. Copyright 2014 American Chemical Society.