Figure 5. Binding density of LL-37 on the surface of mammalian and microbial cells.
Cell suspensions were incubated with 5 μg/ml 125I-LL-37-GY for 20 min at 22 °C. Non-bound peptide was removed by centrifugation at 200g (mammalian cells) or 2000g (bacteria) for 10 min. The pellet was washed with PBS, re-suspended in 100 μl PBS and radioactivity was measured. The adsorption of 125I-LL-37-GY to Immulon wells is described in the legend to Supplemental Fig. 1. The data shown are the mean ± S.E. from 3 experiments each with duplicate measurements.