Table 3.

Association between first trimester circulating immune biomarkers and preeclampsia

	All PE (n=64) a HR (95% CI)	Raw p-value	b Adjusted p-value	Preterm PE (n=10) a HR (95% CI)	Raw p-value	b Adjusted p-value	Term PE (n=54) a HR (95% CI)	Raw p-value	b Adjusted p-value
IFNγ	1.2 (0.7–2.2)	0.4853	0.9493	3.5 (1.4–8.5)	0.0063	0.1134	0.9 (0.5–1.8)	0.8645	0.9493
IL1β	1.2 (0.8–1.8)	0.4928	0.9493	3.6 (1.7–7.6)	0.0006	0.0216	0.9 (0.6–1.5)	0.8240	0.9493
IL4	1.0 (0.7–1.5)	0.8036	0.9493	1.2 (0.6–2.6)	0.4880	0.9493	1.0 (0.7–1.5)	0.9493	0.9493
IL4r	1.1 (0.8–1.6)	0.4645	0.9493	1.5 (0.7–2.8)	0.2754	0.8019	1.1 (0.8–1.5)	0.6458	0.9493
IL5	1.0 (0.7–1.6)	0.6725	0.9493	2.1 (1.0–4.2)	0.0422	0.5064	0.9 (0.6–1.5)	0.8217	0.9493
IL8	1.0 (0.8–1.4)	0.8410	0.9493	0.8 (0.4–1.8)	0.6351	0.5885	1.0 (0.8–1.4)	0.8977	0.9493
IL6	1.3 (0.9–1.9)	0.1431	0.6244	1.5 (0.8–3.0)	0.1750	0.6886	1.3 (0.9–1.8)	0.2543	0.7629
IL6r	0.9 (0.7–1.4)	0.9445	0.9493	1.0 (0.5–2.0)	0.8894	0.9493	1.0 (0.5–2.0)	0.8981	0.9493
IL10	1.1 (0.8–1.7)	0.4894	0.9493	1.6 (0.8–3.2)	0.2060	0.7063	1.1 (0.7–1.6)	0.7499	0.9493
IL12	1.6 (1.1–2.6)	0.0255	0.5064	2.2 (1.0–5.0)	0.0589	0.5774	1.6 (1.0–2.5)	0.0655	0.5648
MIF	1.0 (0.7–1.4)	0.8925	0.9493	0.8 (0.4–1.7)	0.5518	0.9493	1.0 (0.7–1.5)	0.9201	0.9493
MIP	1.2 (0.8–1.7)	0.3866	0.9278	1.7 (0.9–3.4)	0.0973	0.5838	1.1 (0.7–1.6)	0.6814	0.9493
TGFβ	1.2 (0.9–1.7)	0.2741	0.7739	1.5 (0.8–3.1)	0.2361	0.7555	1.2 (0.8–1.7)	0.4155	0.9493
TNFα	0.9 (0.6–1.5)	0.7802	0.9493	0.9 (0.4–2.5)	0.8184	0.9493	0.9 (0.6–1.6)	0.8230	0.9493
TNFβ	1.1 (0.6–2.1)	0.7305	0.9493	2.1 (0.7–5.9)	0.1786	0.6886	1.0 (0.5–1.9)	0.9341	0.9493
TNFr	0.9 (0.6–1.2)	0.3470	0.8766	2.0 (1.0–3.6)	0.0460	0.5462	0.8 (0.5–1.1)	0.1138	0.5885

^aHazard ratio (HR) and 95% confidence intervals (CI) were calculated using cox regression. Hazard ratios can be interpreted as adjusted odds ratios (Dinse et al.) All models were adjusted for maternal age, fetal sex, BMI, SES, gestational age at blood draw and smoking

^bAdjusted for multiple comparisons