Table 4.

Association between second trimester immune biomarkers and preeclampsia

	All PE (n=144) a HR (95% CI)	Raw p-value	b Adjusted p-value	Preterm PE (n=27) a HR (95% CI)	Raw p-value	b Adjusted p-value	Term PE (n=117) a HR (95% CI)	Raw p-value	b Adjusted p-value
IFNγ	0.9 (0.6–1.4)	0.5997	0.9687	0.8 (0.3–1.9)	0.5965	0.9687	0.9 (0.6–1.4)	0.7395	0.9687
IL1β	0.7 (0.5–0.9)	0.0180	0.5350	0.6 (0.4–1.1)	0.0860	0.7559	0.7 (0.5–0.9)	0.0454	0.5350
IL4	0.8 (0.6–1.1)	0.2394	0.6760	1.0 (0.6–1.6)	0.9968	0.9968	0.8 (0.6–1.1)	0.1743	0.6436
IL4r	1.0 (0.6–1.1)	0.1089	0.5350	0.9 (0.6–1.4)	0.6518	0.9687	0.8 (0.6–1.0)	0.0962	0.5350
IL5	1.1 (0.8–1.4)	0.5383	0.9687	1.5 (0.9–2.3)	0.1226	0.5350	1.0 (0.8–1.4)	0.8977	0.9968
IL8	1.0 (0.7–1.3)	0.9674	0.9968	0.6 (0.4–1.2)	0.2218	0.6760	1.1 (0.8–1.4)	0.6390	0.9687
IL6	1.1 (0.8–1.3)	0.9510	0.9968	1.1 (0.7–1.7)	0.7011	0.9687	1.0 (0.7–1.3)	0.9292	0.9968
IL6r	1.0 (0.8–1.3)	0.8437	0.9968	1.1 (0.7–1.8)	0.5325	0.9687	1.0 (0.8–1.3)	0.9915	0.9968
IL10	0.8 (0.6–1.1)	0.1582	0.6328	1.0 (0.6–1.6)	0.9877	0.9968	0.8 (0.6–1.1)	0.1074	0.5350
IL12	0.8 (0.6–1.2)	0.2260	0.6760	1.1 (0.6–1.9)	0.8394	0.9968	0.9 (0.6–1.2)	0.4044	0.9243
MIF	1.1 (0.8–1.3)	0.6853	0.9687	0.9 (0.6–1.4)	0.5684	0.9687	1.1 (0.8–1.4)	0.5944	0.9687
MIP	0.9 (0.7–1.1)	0.3212	0.7709	0.8 (0.5–1.3)	0.2384	0.6760	0.9 (0.7–1.2)	0.4647	0.9687
TGFβ	0.8 (0.6–0.9)	0.0292	0.5350	0.7 (0.4–1.1)	0.1173	0.5350	0.8 (0.6–1.0)	0.0642	0.5350
TNFα	1.1 (0.8–1.5)	0.7669	0.9687	0.9 (0.5–1.7)	0.7224	0.9687	1.1 (0.8–1.5)	0.6249	0.9687
TNFβ	0.7 (0.4–1.1)	0.1158	0.5350	0.4 (0.1–1.2)	0.1028	0.5350	0.8 (0.5–1.2)	0.2711	0.7229
TNFr	1.0 (0.8–1.3)	0.7468	0.9687	1.0 (0.6–1.6)	0.9493	0.9968	1.0 (0.8–1.3)	0.7300	0.9687

^aHazard ratio (HR) and 95% confidence intervals (CI) were calculated using cox regression. Hazard ratios can be interpreted as adjusted odds ratios (Dinse et al.) All models were adjusted for maternal age, BMI, SES, gestational age at blood draw and smoking

^bAdjusted for multiple comparisons