. 2016 Aug 3;19(1):59–67. doi: 10.1093/ntr/ntw199

Table 2.

p Values for Tests of Interactions Between Baseline CES-D Score and Nicotine Content, and Mean Differences Between the RNC and NNC Conditions at Post-randomization Week 6 in Participants With CES-D Scores < 16 vs. ≥ 16

Outcome	Interaction tests		CES-D < 16				CES-D ≥ 16
	Unadjusted model^a	Adjusted model^b	Unadjusted model^a		Adjusted model^b		Unadjusted model^a		Adjusted model^b
	p	p	Mean difference	p	Mean difference	p	Mean difference	p	Mean difference	p
Drinks per day (75th percentile)	.35	.30	0.1 (−0.3, 0.4)	.48	0.01 (−0.22, 0.25)	.96	0.6 (−0.4, 1.7)	1	0.5 (−0.2, 1.2)	1
Cannabis use^c	.19	.11	1.0 (0.9, 1.0)	.73	1.0 (0.9, 1.1)	.81	1.1 (0.9, 1.3)	.27	1.1 (1.0, 1.3)	.15
CPD	.44	.47	−6.4 (−7.7, −5.1)	<.001	−6.3 (−7.6, −5)	<.001	−5.1 (−8.2, −1.9)	.002	−5.5 (−8.7, −2.4)	.001
TNE^d	.40	.41	0.5 (0.4, 0.6)	<.001	0.5 (0.41, 0.62)	<.001	0.4 (0.2, 0.6)	<.001	0.4 (0.3, 0.7)	.001
Breath CO	.52	.42	−0.7 (−2, 0.6)	.27	−0.6 (−1.9, 0.7)	.36	−2.2 (−5.1, 0.7)	.14	−2.1 (−5.1, 0.9)	.17
FTND	.99	.88	−0.8 (−1.1, −0.6)	<.001	−0.8 (−1.1, −0.5)	<.001	−0.8 (−1.5, −0.1)	.03	−1 (−1.7, −0.2)	.01
Total puff volume	.06	.10	−109 (−151, −67)	<.001	−103 (−144, −61)	<.001	1.8 (−108, 111)	.97	−4.0 (−117, 109)	.95
CES-D Total	.03	.03	0.3 (−1.1, 1.7)	.64	0.2 (−1.2, 1.6)	.77	−4.4 (−8.4, −0.4)	.03	−4.8 (−8.7, −0.9)	.02
Depressed	.03	.03	0.3 (−0.2, 0.8)	.23	0.3 (−0.3, 0.8)	.35	−1.4 (−3, 0.2)	.10	−1.8 (−3.3, −0.2)	.03
Positive	.85	.99	0 (−0.4, 0.5)	.92	0 (−0.5, 0.5)	.99	0.3 (−1, 1.6)	.69	0.2 (−1.2, 1.6)	.77
Somatic	.01	.01	0 (−0.5, 0.6)	.90	0 (−0.6, 0.5)	.88	−1.9 (−3.5, −0.3)	.02	−2.1 (−3.7, −0.6)	.01
Interpersonal	.19	.18	0 (−0.1, 0.2)	.75	0 (−0.2, 0.2)	.88	−0.3 (−0.9, 0.3)	.36	−0.3 (−1, 0.3)	.29
WISDM total	.66	.66	−3.2 (−5, −1.5)	<.001	−3.6 (−5.3, −1.9)	<.001	−1.8 (−5.9, 2.2)	.38	−2.9 (−6.7, 1)	.15
QSU Factor 1	.91	.99	−4 (−5.3, −2.7)	<.001	−4 (−5.3, −2.7)	<.001	−4 (−7.6, −0.4)	.03	−4.3 (−8, −0.5)	.03
QSU Factor 2	.26	.30	−1.6 (−2.6, −0.7)	.001	−1.6 (−2.6, −0.7)	.001	−3.4 (−5.9, −0.9)	.01	−3.7 (−6.3, −1.1)	.01
MNWS	.87	.67	−0.5 (−1.2, 0.3)	.22	−0.5 (−1.3, 0.2)	.14	−0.7 (−2.8, 1.4)	.52	−1.3 (−3.4, 0.7)	.20
PANAS positive	.73	.52	−0.7 (−1.9, 0.5)	.27	−0.7 (−1.9, 0.5)	.26	−0.5 (−3.5, 2.5)	.76	−0.2 (−3.3, 3)	.91
PANAS negative	.09	.06	0.2 (−0.7, 1.1)	.74	0 (−0.9, 0.9)	.96	−2.2 (−4.9, 0.6)	.13	−2.7 (−5.3, −0.2)	.04
Noncompliance^c	.12	.15	1.3 (1.2, 1.4)	<.001	1.3 (1.2, 1.4)	<.001	1.1 (0.9, 1.4)	.34	1.1 (0.9, 1.4)	0.29
Quit attempt^c	.96	.90	1.9 (1.2, 2.9)	.01	1.9 (1.2, 2.9)	.01	1.9 (0.7, 5.6)	.23	2.9 (0.8, 10.2)	.10

Bold values are statistically significant. CES-D = Center for Epidemiologic Studies Depression Scale; CO = carbon monoxide; CPD = cigarettes per day; FTND = Fagerström Test of Nicotine Dependence; MNWS = Minnesota Nicotine Withdrawal Scale; NNC = normal-nicotine content; PANAS = Positive and Negative Affect Scale; QSU = Questionnaire on Smoking Urges; RNC = reduced-nicotine content; TNE = total nicotine equivalents; WISDM = Wisconsin Inventory of Smoking Dependence Motives.

^aAdjusted for baseline value only.

^bAdjusted for age, race (white, African American, other), sex, education (≤12 vs. >12 y), and nicotine metabolite ratio, along with baseline value.

^cTreatment effect represented by odds ratios.

^dTreatment effect represented by ratio of geometric means.