. 2016 Aug 3;19(1):59–67. doi: 10.1093/ntr/ntw199

Table 3.

Mean Differences Between the RNC and NNC Conditions at the Abstinence Visit in Patients With CES-D Scores < 16 vs. ≥ 16

Outcome	Interaction tests		CES-D < 16				CES-D ≥ 16
	Unadjusted model^a	Adjusted model^a	Unadjusted model^a		Adjusted model^b		Unadjusted Model^a		Adjusted Model^b
	p	p	Mean difference	p	Mean difference	p	Mean difference	p	Mean difference	p
QSU Factor 1	.52	.44	−9.8 (−11.8, −7.9)	<.001	−9.9 (−11.9, −8)	<.001	−7.4 (−12.9, −1.9)	.01	−7.8 (−13.3, −2.3)	.01
QSU Factor 2	.83	.85	−5.1 (−6.5, −3.7)	<.001	−5.2 (−6.6, −3.7)	<.001	−5.2 (−9.1, −1.2)	.01	−5.9 (−10, −1.9)	.01
MNWS	.49	.56	−2.4 (−3.6, −1.2)	<.001	−2.5 (−3.6, −1.3)	<.001	−1.3 (−4.7, 2)	.44	−1.5 (−5.1, 2)	.40

Bold values are statistically significant. CES-D = Center for Epidemiologic Studies Depression Scale; MNWS = Minnesota Nicotine Withdrawal Scale; NNC = normal-nicotine content; QSU = Questionnaire on Smoking Urges; RNC = reduced-nicotine content.

^aAdjusted for baseline value only.

^bAdjusted for age, race (white, African American, other), sex, education (≤12 vs. >12 y), and nicotine metabolite ratio, along with baseline value.