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The anti‐CII IC‐induced upregulation of CXCL8 in PMN + PBMC cocultures can not be mimicked by LPS. (A and B) Production of (A) TNF‐α and (B) CXCL8 from PBMC (P) or PBMC + PMN cocultures (CoC). The effects of LPS on surfaces of HSA or collagen type II (CII) are compared with stimulation by plate‐bound IgG (P‐IgG) or anti‐CII IC. Data are pooled from four experiments with four donors each (total 16 donors). Paired investigations were made with the Wilcoxon test.
