. 2016 Dec 7;13:215–222. doi: 10.1016/j.nicl.2016.12.003

Table 2.

Global and regional differences between groups.

Total values	Model	Effect	Coefficient (s.e.)	p
Total cortical volume	Cubic	ASD < controls	− 16,168 (7351.007)	0.029^⁎
Total cortical surface area	Linear	Interaction	− 4058 (2274.939)	0.006^⁎⁎
Average cortical thickness	Linear			n.s.
Total subcortical grey volume	Quadratic	ASD < controls	(0.000)	0.013^⁎

Cortical regions		Volume			Area				Thickness
Cortical regions		Model	Effect	Coefficient (s.e.)	p	Model	Effect	Coefficient (s.e.)	p	Model Effect	Coefficient (s.e.)	p
Banks of the superior temporal sulcus	LH	Linear	Interaction	58.676 (20.461)	0.006^⁎⁎	Linear	Interaction	23.937 (6.221)	< 0.001^⁎⁎⁎
Banks of the superior temporal sulcus	RH
Fusiform gyrus	LH	Linear	ASD < controls	− 490.290 (233.826)	0.037^⁎
Fusiform gyrus	RH
Inferior parietal gyrus	LH	Linear	ASD < controls	− 747.147 (326.604)	0.023^⁎	Linear	Interaction	71.661 (22.445)	0.002^⁎⁎
Inferior parietal gyrus	RH	Quadratic	ASD < controls	− 1065.281 (337.490)	0.002^⁎⁎
Inferior temporal gyrus	LH	Quadratic	ASD < controls	− 668.350 (275.820)	0.016^⁎					Linear interaction	− 0.015 (0.007)	0.034^⁎
Inferior temporal gyrus	RH
Middle temporal gyrus	LH	Linear	ASD < controls	− 603.961 (262.943)	0.023^⁎	Linear	Interaction	43.329 (14.886)	0.005^⁎⁎
Middle temporal gyrus	RH	Linear	ASD < controls	− 749.827 (284.885)	0.009^⁎⁎	Linear	ASD < controls	− 153.013 (61.455)	0.014^⁎
Postcentral gyrus	LH	Linear	Interaction	132.449 (49.699)	0.010^⁎⁎	Linear	Interaction	68.735 (18.662)	< 0.001^⁎⁎⁎
Postcentral gyrus	RH	Linear	ASD < controls	− 666.695 (220.440)	0.003^⁎⁎	Linear	Interaction	37.573 (18.488)	0.046^⁎
Precentral gyrus	LH	Quadratic	ASD < controls	− 505.051 (249.349)	0.044^⁎	Linear	Interaction	57.802 (23.864)	0.018^⁎
Precentral gyrus	RH
Rostral anterior cingulate	LH	Linear	ASD < controls	− 190.958 (82.488)	0.022^⁎	Linear	ASD < controls	− 44.762 (20.745)	0.032^⁎
Rostral anterior cingulate	RH
Superior frontal gyrus	LH	Cubic	ASD < controls	− 924.217 (450.579)	0.042^⁎	Linear	Interaction	56.931 (25.701)	0.030^⁎	Cubic interaction	0.002 (0.001)	0.041^⁎
Superior frontal gyrus	RH	Cubic	ASD < controls	− 1055.331 (457.772)	0.022^⁎	Linear	ASD < controls		0.045^⁎
Superior parietal gyrus	LH	Cubic	Interaction	13.972 (6.740)	0.042^⁎
Superior parietal gyrus	RH
Supramarginal gyrus	LH	Linear	ASD < controls	− 697.218 (289.830)	0.017^⁎	Linear	Interaction	39.861 (19.095)	0.040^⁎
Supramarginal gyrus	RH	Linear	ASD < controls	− 678.204 (282.140)	0.017^⁎	Linear	Interaction	64.310 (17.907)	< 0.001^⁎⁎⁎
Insula	LH	Cubic	ASD < controls	− 256.943 (129.449)	0.049	Linear	ASD < controls	− 80.474 (33.315)	0.017^⁎
Insula	RH	Linear	ASD < controls	− 301.071 (130.657)	0.022^⁎	Quadratic	ASD < controls	− 97.039 (35.805)	0.007^⁎⁎
Lingual gyrus	LH
Lingual gyrus	RH	Cubic	Interaction	7.000 (2.926)	0.020^⁎
Posterior cingulate gyrus	LH
Posterior cingulate gyrus	RH	Linear	Interaction	38.199 (18.793)	0.046^⁎					Linear interaction	− 0.014 (0.007)	0.036^⁎
Precuneus	LH
Precuneus	RH	Linear	ASD < controls	− 571.046 (225.564)	0.012^⁎	Linear	Interaction	28.825 (14.128)	0.045^⁎

Regression coefficients and p-values of main group and group ∗ age interaction terms are provided in the table. ASD, autism spectrum disorder; TD, typical development; LH, left hemisphere; RH, right hemisphere; n.s., not significant.

^⁎

p < 0.05.

^⁎⁎

p < 0.01.

^⁎⁎⁎

p < corrected for multiple comparisons using singular value decomposition