Table 4.
Proteins of significant association with resistance to metronidazole, levofloxacin, and/or clarithromycin in all of the 18 H. pylori strains tested using Fisher's exact test (2-tailed, p < 0.05 is considered significant).
| Protein | Protein description/function | Antibiotic resistance | Fisher's exact test (p-value) |
|---|---|---|---|
| UvrB | UvrABC system protein B | Levofloxacin | 0.014 |
| Jhp_0525 | Putative protein | Levofloxacin | 0.031 |
| Jhp_0602 | Putative processing protease | Levofloxacin | 0.031 |
| Jhp_0260 | Putative protein | Levofloxacin | 0.032 |
| CarB | Carbamoyl-phosphate synthase large chain | Levofloxacin | 0.033 |
| ClpP | Chaperone protein | Metronidazole | 0.007 |
| Jhp_0892 | Putative protein | Metronidazole | 0.007 |
| SerA (Jhp_0984) | D-3-phosphoglycerate dehydrogenase | Metronidazole | 0.007 |
| Efp (Jhp_0163) | Elongation factor P | Metronidazole | 0.022 |
| HypB (Jhp_0837) | Hydrogenase/urease nickel incorporation protein HypB | Metronidazole | 0.022 |
| IleS (Jhp_1317) | Isoleucine-tRNA ligase | Metronidazole | 0.022 |
| ProS (Jhp_0067) | Urease subunit beta | Metronidazole | 0.022 |
| RplF (Jhp_1224) | 50S ribosomal protein L6 | Metronidazole | 0.022 |
| RpsS (Jhp_1235) | 30S ribosomal protein S19 | Metronidazole | 0.022 |
| PyrF (Jhp_0005) | Orotidine 5′-phosphate decarboxylase | Metronidazole | 0.031 |
| RpsI (Jhp_0076) | 30S ribosomal protein S9 | Metronidazole | 0.031 |
| Jhp_0844 | Flagellar basal body protein | Metronidazole, levofloxacin | 0.042 |
| Jhp_1071 | Putative protein | Metronidazole, levofloxacin | 0.042 |
| Jhp_1303 | Putative protein | Metronidazole, levofloxacin | 0.042 |
| CysS (Jhp_0818) | Cysteine-tRNA ligase | Metronidazole, levofloxacin | 0.042 |
These proteins were up-regulated in the levofloxacin and metronidazole resistant H. pylori strains.