Table 3.
Liver biopsy characteristics
| Cases | NASH controls | |||||
|---|---|---|---|---|---|---|
| Histopathological features | ||||||
| Steatosis percentage | >66% (n=2) | 33–66% (n=4) | <33% (n=2) | >66% (n=3) | 33–66% (n =2) | <33% (n =1) |
| Steatosis location | Uniform (n=4) | Central lobular sparing (n =4) | Uniform (n=5) | Central lobular sparing (n=0) | Portal vein sparing (n =1) | |
| Brunt system | ||||||
| Brunt gradea | Grade 1 (n=3) | Grade 2 (n =3) | Grade 3 (n =2) | Grade 1 (n =3) | Grade 2 (n=3) | Grade 3 (n=0) |
| Brunt stageb | Stage 0–1 (n =2) | Stage 2 (n=5) | Stage 3 or 4 (n =1) | Stage 1 (n=3) | Stage 2 (n =2) | Stage 3 or 4 (n=1) |
| NCRNc | ||||||
| Inflammation | 0–1 (n=7) | 2 (n=1) | 3 (n=0) | 0–1 (n=4) | 2 (n=2) | 3 (n=0) |
| Steatosis | 0–1 (n=2) | 2 (n=4) | 3 (n=2) | 0–1 (n=1) | 2 (n=2) | 3 (n=3) |
| Ballooning | 0–1 (n=6) | 2 (n=2) | 3 (n=2) | 0–1 (n=5) | 2 (n=1) | 3 (n=0) |
| Fibrosis | 0–1 (n=3) | 2 (n=3) | 3&4 (n=1) | 0–1 (n=3) | 2 (n=2) | 3 (n=1) |
| Other findings | ||||||
| Granulomas | n =4 | N=0 | ||||
| Lipogranulomas | n =2 | N=0 | ||||
NCRN, Nonalcoholic steatohepatitis Clinical Research Network; NASH, nonalcoholic steatohepatitis.
a
Brunt grade (numerical score of three features: inflammation, steatosis, and ballooning (1, mild; 2, moderate; and 3, severe).
b
Brunt STAGE (numerical score based on the severity of fibrosis: zone 3 fibrosis, 1; zone 3 and portal fibrosis, 2; bridging fibrosis, 3; and cirrhosis, 4).
c
NCRN [summation of scores for [steatosis (0–3), inflammation (0–3), and ballooning (0–1)] and fibrosis (portal fibrosis, 1 a–c), (perisinusoidal and portal fibrosis, 2), (bridging fibrosis, 3), and (cirrhosis, 4)].