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. 2016 Oct 21;6(4):311–318. doi: 10.1016/j.jceh.2016.10.001

Table 2.

Established Criteria for Biochemical Response to Urosdeoxycholic Acid.

Criteria
Author
Biochemical endpoints Evaluation time Clinical endpoints
Barcelona63
Parès
ALP 40% decrease or normalization 1 year Transplant-free survival
Mayo64
Mohma
ALP < 2 times ULN and/or Mayo risk score <4.5 2 year Transplant-free survival
Paris65
Corpechot
ALP <3 times ULN and ALT <2× ULN and bilirubin <1 mg/dl 1 year Transplant-free survival
Paris II66
Corpechot
ALP < 1.5 times ULN and ALT < 1.5 times ULN and bilirubin < 1 mg/dl 1 year Transplant-free survival, liver decompensation (ascites, HCC, variceal bleeding, PSE)
Rotterdam67
Kuiper
Normalization of bilirubin and albumin 1 year Transplant-free survival
Toronto68
Kumagi
ALP < 1.67 times ULN 2 year Histology

Abbreviations: ALP: alkaline phosphatase; ALT: alanine aminotransferase; ULN: upper limit of normal; HCC: hepatocellular carcinoma; PSE: portosystemic encephalopathy.