Table 2.
Established Criteria for Biochemical Response to Urosdeoxycholic Acid.
Criteria Author |
Biochemical endpoints | Evaluation time | Clinical endpoints |
---|---|---|---|
Barcelona63 Parès |
ALP 40% decrease or normalization | 1 year | Transplant-free survival |
Mayo64 Mohma |
ALP < 2 times ULN and/or Mayo risk score <4.5 | 2 year | Transplant-free survival |
Paris65 Corpechot |
ALP <3 times ULN and ALT <2× ULN and bilirubin <1 mg/dl | 1 year | Transplant-free survival |
Paris II66 Corpechot |
ALP < 1.5 times ULN and ALT < 1.5 times ULN and bilirubin < 1 mg/dl | 1 year | Transplant-free survival, liver decompensation (ascites, HCC, variceal bleeding, PSE) |
Rotterdam67 Kuiper |
Normalization of bilirubin and albumin | 1 year | Transplant-free survival |
Toronto68 Kumagi |
ALP < 1.67 times ULN | 2 year | Histology |
Abbreviations: ALP: alkaline phosphatase; ALT: alanine aminotransferase; ULN: upper limit of normal; HCC: hepatocellular carcinoma; PSE: portosystemic encephalopathy.