Table 3.
Diagnostic Performances of APRI and FIB4 Scores for Predicting Significant Fibrosis and Cirrhosis.
| Significant fibrosis (LSM ≥ F2) | |||||
|---|---|---|---|---|---|
| Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | +LR/−LR | |
| FIB4 (cutoff 1.25) | 73.6 | 68.3 | 74.0 | 67.9 | 2.3/0.4 |
| APRI (cutoff 0.5) | 91.2 | 32.4 | 62.4 | 75.0 | 1.2/0.3 |
| Combination (FIB4 + APRI) | 73.0 | 70.2 | 75.2 | 68.0 | 2.5/0.4 |
| Advanced fibrosis/cirrhosis (LSM = F4) | |||||
| FIB4 (cutoff 3.25) | 57.9 | 95.7 | 84.6 | 84.9 | 13.4/0.4 |
| APRI (cutoff 2) | 49.5 | 92.8 | 73.4 | 81.9 | 6.9/0.5 |
| Combination (FIB4 + APRI) | 48.4 | 96.6 | 85.2 | 85.4 | 14.2/0.5 |
PPV, positive predictive value; NPV, negative predictive value; +LR, positive likelihood ratio; −LR, negative likelihood ratio.