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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Curr HIV Res. 2016;14(5):431–441. doi: 10.2174/1570162x14666160324125536

Figure 2.

Figure 2

ART therapy reduces mutation rate of the LTR by an average of 1.1 mutations per Kb per year. A) A histogram of the average mutation rate per patient while naive to therapy (blue) and after virologic control on cART (green). B) A cumulative normalized histogram of the same data in A) showing the fraction of patients with a mutation rate. Fourty two non-drug using patients that currently have undetectable viral load and at least 5 years in the study were selected. from the Drexel Medicine CNS AIDS Research and Eradication Study (CARES) Cohort. The LTR region was PCR amplified from genomic DNA isolated from PBMCs and phylogenetic trees were constructed to estimate the time varying mutation rate of the virus.