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. 2016 Dec 15;12(12):e1006232. doi: 10.1371/journal.pgen.1006232

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© 2016 Amândio et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — A-B) Differential gene expression analysis between wild type and Del(Hotair)^-/- trunk tissues (T1, T2, T3). The absolute fold change is > 1.5 and FDR < 0.05. The different columns correspond to sample type and rows correspond to differentially expressed genes. (A) Heat map of centered and scaled gene expression levels (Z-score log2 RPKM). Genes are color coded vertically, according to tissue and expression changes between genotypes. (B) Venn diagram showing the number of down-regulated (top) and up-regulated (bottom) genes. C-D) Differential gene expression analysis between wild type and Del(Hotair)^-/- forelimbs (FL), hindlimbs (HL) and genital tubercle (GT). The absolute fold change is > 1.5 and FDR < 0.05. (C) Heat map of centered and scaled gene expression levels (Z-score log2 RPKM). Genes are color coded vertically according to the tissue and orientation of expression between genotypes. (D) Venn diagram showing the number of down-regulated (top) and up regulated (bottom) genes.