Table 1. Phenotypic analysis of wild type and Del(Hotair)-/- skeletons at post-natal day 22 (P22).
wt | Del(Hotair)+/- | Del(Hotair)-/- | |
---|---|---|---|
(n = 11) | (n = 11) | (n = 10) | |
Lumbar vertebrae | |||
L6 | 1 | 1 | 1 |
L6/S1* | 2 | 1 | 1 |
L5 | 8 | 9 | 8 |
Wrist | |||
normal | 11 | 11 | 10 |
ill-formed | 0 | 0 | 0 |
Ankle | |||
normal | 11 | 11 | 10 |
ill-formed | 0 | 0 | 0 |
* Mixed identity
Various control and mutant specimen were scored for having either five lumbar vertebrae (L5), six (L6) or a mixed L5-6/S1 vertebra. The mesopodial bones (wrist and ankle) were found normal in shape and number in all cases.