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. 2016 Dec 20;68(24):2652–2666. doi: 10.1016/j.jacc.2016.09.946

Figure 4.

Figure 4

Cardiomyocyte Hypertrophy

(A) Heart images at 8 weeks (scale bar = 5 mm). (B) Ratio of HW to TL. *p <0.05, **p <0.01 versus sham. n = 10, 10, 9, and 8 for, sham, MI, MI/AAVGFP, and MI/AAVAng-(1-9), respectively. Data presented as mean ± SEM. (C) Cardiac cross sections in transverse axis (original main image magnification ×25; scale = 50 μm; inset zoom image scale = 12.5 μm). (D) LV cardiomyocyte diameter in hearts. ***p <0.001 versus sham. n = 10, 10, 9, and 8 for sham, MI, MI/AAVGFP, and MI/AAVAng-(1-9), respectively. (E) Cardiac cross sections in longitudinal axis (original main image magnification = ×25; scale = 50 μm; inset zoom image scale = 50 μm). (F) LV cardiomyocyte length. n = 10, 10, 9, and 8 for sham, MI, MI/AAVGFP, and MI/AAVAng-(1-9), respectively. Data presented as mean ± SEM with average cell size taken as average of a group of cells evenly distributed across LV. HW = heart weight; TL = tibia length; other abbreviations as in Figures 1 and 2.