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. 2016 Dec 20;68(24):2652–2666. doi: 10.1016/j.jacc.2016.09.946

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© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Excitation Contraction Coupling in hiPSC-CMs

(A) Representative Ca²⁺-transient traces from Ang-(1-9)-treated cells. (B) Average Ca²⁺-transient amplitude for iCell² hiPSC-CM (Cellular Dynamics International, Madison, Wisconsin). (C) Contractility traces. (D) Average contraction amplitude for iCell² hiPSC-CMs. *p <0.05 versus control. Data presented as mean ± SEM (n = 5). Red trace = 1 Hz stimulation. hiPSC-CM = human-induced pluripotent stem cell-derived cardiomyocytes; other abbreviation as in Figure 1.