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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Expert Rev Clin Immunol. 2016 Jun 13;12(11):1239–1249. doi: 10.1080/1744666X.2016.1196138

Figure 4. TREM-2 signaling mediated through DAP12 and downstream kinases leading to the expression of anti- inflammatory genes.

Figure 4

TREM-2 ligand binding activates DAP12 and downstream Syk and ZAP-70 (Zeta-chain-associated protein kinase 70) which in turn activate PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase) pathway resulting in Ca2+ influx. Ca2+ activates NFAT (nuclear factor of activated T cells) by phosphorylation through calmodulin kinase. NFAT translocates to nucleus and triggers the expression of anti-inflammatory genes. PI3K inhibits TLR (toll-like receptor) signaling via Akt pathway which in turn inhibits inflammation.