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. 2016 Dec 15;11(12):e0168072. doi: 10.1371/journal.pone.0168072

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© 2016 Ho et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — SHIP-/-, but not +/+, basophils constitutively secrete sufficient IL-4 to M2 skew SHIP+/+ or -/- progenitors or mature MФs but only in the presence of ATRA, TGFβ and PGE₂ in MP. These MP factors synergize with low levels of IL-4 to M2 skew the MФs under non-inflamed conditions.