Fig 5.
A. Analysis of the effects of STAT3-knockdown in N2a cells. In N2a cells transfected with 200 nM of STAT3 siRNA, STAT3 protein levels were reduced to ~ 30% of the level of negative controls. B. In STAT3 gene-silenced cells, Aβ1–42 did not elevate NF-κB p65 (B) or BACE1 levels (C), whereas it did so in cells transfected with scrambled siRNA duplex (negative control). Results are the means ± SEMs of 4 experiments. $ $ $P < 0.01, $ $ $P < 0.001 vs. Negative control; *P < 0.05, ***P < 0.001 vs. Vehicle (Veh).