Table 2. Transcript expression in the soleus.

Data are shown as fold change relative to C57. * indicates significantly different from C57; # indicates significantly different from mdx. C57 (n = 7) mdx (n = 6) mdxQ (n = 6).

	C57	Mdx	mdxQ
	Average ± SEM	Average ± SEM	Average ± SEM
Mitochondrial Biogenesis (PGC-1α Pathway Genes)
Sirt1	1.00 ± 0.25	2.02 ± 0.45	1.94 ± 0.54
Ppargc1a (Pgc-1α)	1.00 ± 0.11	-1.67 ± 0.09*	-1.72 ± 0.09*
Esrra (Errα)	1.00 ± 0.18	-3.47 ± 0.11*	-2.65 ± 0.06*
Nrf1	1.00 ± 0.23	-1.93. ± 0.11	-1.24 ± 0.28
Nrip1	1.00 ± 0.18	-1.45 ± 0.20	-1.46 ± 0.21
Tfam	1.00 ± 0.48	-1.34 ± 0.16	-2.07 ± 0.11
Metabolic Genes
Fnip1	1.00 ± 0.25	-1.84 ± 0.06	-2.08 ± 0.04
Mtor	1.00 ± 0.27	-2.48 ± 0.12*	-2.57 ± 0.10*
Prkaa1	1.00 ± 0.16	-1.05 ± 0.14	-1.72 ± 0.12
Gapdh	1.00 ± 0.20	-3.48 ± 0.04*	-2.97 ± 0.04*
Pfkm	1.00 ± 0.16	-2.38 ± 0.04*	-2.38 ± 0.06*
Pparg	1.00 ± 0.19	-1.32 ± 0.27	-1.18 ± 0.40
Cs	1.00 ± 0.16	-3.64 ± 0.05*	-3.60 ± 0.04*
Mdh1	1.00 ± 0.15	-1.94 ± 0.07*	-2.27 ± 0.08*
Atp1a2	1.00 ± 0.07	-1.76 ± 0.10*	-2.09 ± 0.06*
Cybb	1.00 ± 0.30	-1.35 ± 0.03	2.77 ± 1.35
Cycs	1.00 ± 0.27	1.11 ± 0.29	-2.45 ± 0.11
Mb	1.00 ± 0.17	-4.35 ± 0.03*	-4.61 ± 0.04*
Mt-atp6	1.00 ± 0.07	-2.14 ± 0.05*	-2.38 ± 0.06*
Mt-co1	1.00 ± 0.17	-2.78 ± 0.04*	-3.18 ± 0.05*
Mt-co2	1.00 ± 0.14	-2.15 ± 0.07*	-2.50 ± 0.06*
Mt-cyb	1.00 ± 0.09	-2.35 ± 0.04*	-2.59 ± 0.06*
Mt-nd1	1.00 ± 0.06	-2.32 ± 0.04*	-2.66 ± 0.06*
Mt-nd4	1.00 ± 0.21	-2.32 ± 0.05*	-2.85 ± 0.06*
Uqcrc1	1.00 ± 0.17	-2.01 ± 0.09*	-2.59 ± 0.05*
Tfb1m	1.00 ± 0.66	-1.49 ± 0.26	-2.95 ± 0.06
Tfb2m	1.00 ± 0.13	-2.50 ± 0.09*	-1.70 ± 0.16
Ucp3	1.00 ± 0.21	-3.50 ± 0.11*	-4.50 ± 0.04*
Ak1	1.00 ± 0.35	-2.68 ± 0.12	-2.18 ± 0.27
Akt1	1.00 ± 0.56	-4.43 ± 0.07	-2.97 ± 0.11
Ckm	1.00 ± 0.15	-1.87 ± 0.08	-1.92 ± 0.10
Inflammation/antioxidant Genes
Nfĸb1	1.00 ± 0.24	-1.35 ± 0.31	-1.10 ± 0.40
Il1b	1.00 ± 0.28	-1.23 ± 0.21	-2.55 ± 0.02
Tlr4	1.00 ± 0.61	-2.18 ± 0.19	-3.56 ± 0.06
Traf2	1.00 ± 0.16	-1.02 ± 0.40	1.23 ± 0.32
Cat	1.00 ± 0.51	-5.53 ± 0.03*	-4.96 ± 0.06*
Gpx1	1.00 ± 0.47	-2.27 ± 0.17	-3.64 ± 0.07
Gpx4	1.00 ± 0.31	-2.29 ± 0.09*	-2.69 ± 0.05*
Gsr	1.00 ± 0.29	2.02 ± 0.93	-1.25 ± 0.17
Nfe2l2	1.00 ± 0.15	-1.98 ± 0.13*	-2.11 ± 0.13*
Prdx2	1.00 ± 0.25	-2.96 ± 0.06*	-4.00 ± 0.04*
Sod1	1.00 ± 0.40	-2.36 ± 0.10	-3.37 ± 0.05*
Sod2	1.00 ± 0.25	-2.64 ± 0.05*	-2.88 ± 0.06*
Apoptosis Genes
Apaf1	1.00 ± 0.27	-1.03 ± 0.07	1.68 ± 0.68
Bax	1.00 ± 0.37	1.12 ± 0.22	1.16 ± 0.28
Bcl2	1.00 ± 0.13	-1.59 ± 0.18	-1.63 ± 0.22
Bnip2	1.00 ± 0.17	-2.45 ± 0.08*	-1.29 ± 0.12*#
Casp3	1.00 ± 0.44	-1.29 ± 0.33	-2.10 ± 0.18
Trp53	1.00 ± 0.33	-2.97 ± 0.14	-1.19 ± 0.47
Xiap	1.00 ± 0.27	-2.05 ± 0.12	-1.92 ± 0.12
Muscle Repair and Protein Turnover Genes
Fbl	1.00 ± 0.35	-1.48 ± 0.21	-1.15 ± 0.26
Gata2	1.00 ± 0.60	-2.16 ± 0.19	-3.78 ± 0.12
Hspa1a	1.00 ± 0.87	-1.88 ± 0.03	-2.47 ± 0.02
Hspa5	1.00 ± 0.36	-2.60 ± 0.07*	-1.97 ± 0.11
Hspb1	1.00 ± 0.21	-1.33 ± 0.18	-1.99 ± 0.11*
Mef2c	1.00 ± 0.17	-1.96 ± 0.09*	-2.68 ± 0.03*
Mstn	1.00 ± 0.26	-1.35 ± 0.19	-1.20 ± 0.21
Myf5	1.00 ± 0.38	-3.32 ± 0.08	-1.39 ± 0.38
Myocd	1.00 ± 0.26	-1.77 ± 0.33	-1.13 ± 0.71
Myod1	1.00 ± 0.67	-1.33 ± 0.53	-2.48 ± 0.15
Myof	1.00 ± 0.58	-2.06 ± 0.19	-2.39 ± 0.15
Myog	1.00 ± 0.59	-2.24 ± 0.17	-4.87 ± 0.07
Poldip2	1.00 ± 0.16	-1.24 ± 0.17	-2.11 ± 0.03*
Tgfb1	1.00 ± 0.10	1.45 ± 0.47	2.10 ± 1.00
Structural and Sarcomeric Genes
Dag1	1.00 ± 0.10	-1.53 ± 0.13*	-2.27 ± 0.07*
Dtna	1.00 ± 0.16	-1.43 ± 0.08	-1.40 ± 0.12
Dysf	1.00 ± 0.16	-1.40 ± 0.15	-1.58 ± 0.10
Myh1	1.00 ± 0.39	-1.22 ± 0.15	-1.78 ± 0.05
Myh2	1.00 ± 0.17	-3.24 ± 0.04*	-3.29 ± 0.06*
Myh7	1.00 ± 0.17	-2.56 ± 0.05*	-2.92 ± 0.09*
Sgca	1.00 ± 0.17	-2.74 ± 0.05*	-3.49 ± 0.06*
Utrn 3’	1.00 ± 0.24	-1.15 ± 0.15	-1.32 ± 0.22
Utrn 5’	1.00 ± 0.15	-1.54 ± 0.14	-1.17 ± 0.32