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. 2016 Dec 15;11(12):e0167016. doi: 10.1371/journal.pone.0167016

Table 2. Cox proportional hazards model for recurrence-free survival and overall survival (n = 262).

A. Univariate analysis
Recurrence-free survival Overall survival
Variable HR 95% CI P value HR 95% CI P value
Age (50< vs. ≤50) 1.8 0.8–5.4 0.19 2.2 0.8–9.4 0.16
Tumor size (2cm< vs. ≤2cm) 3.7 1.8–8.3 0.0003 3.9 1.7–10.2 0.002
Nodal status (Positive vs. Negative) 4.4 2.1–9.4 <0.0001 4.3 1.9–10.7 0.0006
pStage (III vs. I and II) 6.8 3.1–14.1 <0.0001 9.5 4.0–21.9 <0.0001
Nuclear grade (3 vs. 1 and 2) 1.1 0.5–2.4 0.87 1.0 0.4–2.4 0.93
Ki-67 (20%< vs. ≤20%) 1.2 0.4–5.1 0.76 1.0 0.3–4.1 0.96
Basal-like status (Basal-like vs. Non-basal-like) 0.9 0.3–2.9 0.78 1.3 0.4–8.1 0.72
BRCAness status (BRCAness vs. Non-BRCAness) 2.6 1.1–7.8 0.03 3.1 1.1–13.2 0.04
Chemotherapy (Anthra vs. Non-anthra) 0.4 0.2–1.6 0.19 0.4 0.1–2.6 0.29
(Anthra vs. No Treatment) 0.8 0.4–1.9 0.64 0.3 0.1–0.8 0.02
B. Multivariate analysis
Recurrence-free survival Overall survival
Variable HR 95% CI P value HR 95% CI P value
pStage (III vs. I and II) 9.5 4.1–21.1 <0.0001 21.3 7.7–60.1 <0.0001
BRCAness status (BRCAness vs. Non-BRCAness) 3.3 1.3–10.1 0.008 6.3 1.9–29.0 0.002
Chemotherapy (Anthra vs. Non-anthra) 0.2 0.1–0.7 0.02 0.1 0.02–0.7 0.03
(Anthra vs. No Treatment) 0.6 0.2–1.3 0.17 0.2 0.1–0.4 0.0002

HR, hazard ratio; CI, confidence interval; vs., versus; Anthra, Anthracycline-based adjuvant chemotherapy; non-Anthra, Non-anthracycline-based adjuvant chemotherapy.