Skip to main content
. Author manuscript; available in PMC: 2016 Dec 15.
Published in final edited form as: Leukemia. 2016 May 2;30(12):2332–2341. doi: 10.1038/leu.2016.114

Figure 4.

Figure 4

Hematoxylin and eosin sections of bone marrow revealed MK hyperplasia and increased marrow sinusoid density. (a) There was markedly increased numbers of MK in Pf4-Cre/FF1 mice (right) compared with controls (left). (b) Red blood cell-engorged dilated central sinus (*) was observed in 3/3 Pf4/FF1 mice marrow and MKs were preferentially located near sinusoids (S) (top). Quantitative analysis revealed increased marrow sinusoid vascular density in Pf4/FF1 mice (n = 3) marrow compared with controls (n = 2) (2.7-fold, P = 0.010) (bottom).