Fig. 6.

5-AzaC treatment of P7 mice induces long-lasting impairments in spatial memory and social recognition memory in adulthood. Spatial memory performance was measured using the Y-maze. (A) Discrimination index [preference for the novel arm over the familiar other arm (Novel/Novel + Other)] for arm entries and (B) dwell time of the saline- and 5-AzaC-treated male and female mice at 24 h after the first encounter with the partially opened maze. The dashed line denotes chance performance (0.5). (C) The percentage of saline- and 5-AzaC-treated animals (male and female combined) that selected the novel arm as the first choice 24 h after the first encounter with the partially open maze is shown. (D) Exposure to 5-AzaC at P7 induces a loss of social recognition memory in adult male mice. The percent of time spent in social investigation at 24 h after the first encounter with the same juvenile mouse is shown for the saline- and 5-AzaC-treated mice. Error bars, SEM (n = 8 mice/group). *p < 0.01 vs. saline.